There are 12 different rounds. After completing each round, you earn a different rank. For each round, you choose either Series 1, Series 2, or Series 3 Mixels figures. You can combine any two Mixels from any tribes. Depending on whether it turns out to be a regular Mix or a Murp, you will be able to play one of two minigames: Nixel Knockout or Nixel Whack.
- Some of the mixes and murps appear in the shorts.
- Some mixes that are seen in the show don't always appear as mixes in the game.
- The name was changed to Mixels Mania when Series 2 was added.